MYELOID NEOPLASIA Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia
نویسندگان
چکیده
1Department of Internal Medicine IV–Oncology and Hematology, Martin Luther University Halle-Wittenberg, Halle, Germany; 2Department of Medicine, Hematology and Oncology, University of Münster, Münster, Germany; 3Department of Medicine III, University of Munich and Clinical Cooperative Group, HelmholtzZentrum German Research Center for Environmental Health, Munich, Germany; 4Harvard Stem Cell Institute, Harvard Medical School, Boston, MA; and 5Cancer Science Institute, National University of Singapore, Singapore
منابع مشابه
Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia.
Transcription factor CCAAT enhancer binding protein alpha (C/EBPalpha) is essential for granulopoiesis and its function is deregulated in leukemia. Inhibition of E2F1, the master regulator of cell-cycle progression, by C/EBPalpha is pivotal for granulopoiesis. Recent studies show microRNA-223 (miR-223), a transcriptional target of C/EBPalpha, as a critical player during granulopoiesis. In this ...
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تاریخ انتشار 2010